Abstract:

Ocular and adnexal (including the orbit, eyelid, conjunctiva, lacrimal gland and lacrimal sac) lymphoma is a relatively rare ocular malignant tumor, of which the incidence worldwide tends to be gradually increasing lately. They are  the classification of non-Hodgkin's lymphoma at most times. And the most common subtype of ocular and adnexal lymphoma are the highly malignant diffuse large B cell lymphoma and low-grade malignant extranodal marginal zone B cell lymphoma. Most of the ocular and adnexal lymphoma cells are derived from B lymphocytes. Immunohistochemistry often shows that B cell markers (CD79a, CD20, PAX5) are positive. Ki-67 staining is used to test tumor cell growth factor levels, so as to evaluate the malignant degree of lymphoma.   (Int Rev Ophthalmol,  2015,  39:     418-422)